Immunization:

Safety and Use of Polio Vaccines

HRD-87-83BR: Published: May 11, 1987. Publicly Released: May 11, 1987.

Additional Materials:

Contact:

Office of Public Affairs
(202) 512-4800
youngc1@gao.gov

Pursuant to a congressional request, GAO reviewed: (1) actions the federal government took to improve the safety of the oral polio vaccine (OPV); (2) the basis for recommending the use of a live polio vaccine for routine childhood immunization; and (3) the steps required to initiate an inactivated polio vaccine (IPV) for childhood immunization.

GAO found that: (1) federal research efforts to improve the safety of live polio vaccines were adequate; (2) FDA proposed changes to its OPV regulations and manufacturing requirements for future OPV licensed in the United States; and (3) the Immunization Practices Advisory Committee recommended the use of OPV because it could immunize unvaccinated people through contact and provide a higher level of intestinal immunity than IPV. GAO also found that the federal government would have to initiate several actions to recommend IPV for childhood immunization, specifically: (1) licensing a more potent IPV for marketing in the United States; (2) demonstrating the efficacy and safety of a more potent IPV; and (3) reducing the importation of polio viruses into the United States.

Oct 15, 2018

Oct 1, 2018

Sep 28, 2018

Sep 17, 2018

Sep 13, 2018

Sep 10, 2018

Sep 6, 2018

Sep 5, 2018

Sep 4, 2018

Aug 24, 2018

Looking for more? Browse all our products here