This is an Acting Comptroller General presentation given to The National Association of State Auditors, Comptrollers and Treasurers on August 10, 2010. Major topics of this presentation include: threats confronting U.S. national security interests, fiscal sustainability and debt challenges, economic recovery and restored growth, the changing dynamics of global interdependence, advances in science and technology, increasing impact of networks and virtualization, shifting roles in government and governance, and demographic and societal changes confronting young and old.