This is an Acting Comptroller General Presentation delivered to the 18th Biennial Forum of Government Auditors in San Antonio, Texas on May 19, 2010. Major topics of this presentation include: threats confronting U.S. national security interests; fiscal sustainability and debt challenges; economic recovery and restored growth; the changing dynamics of global interdependence; advances in science and technology; increasing impact of networks and virtualization; shifting roles in government and governance; demographic and societal changes confronting young and old; and other new and ongoing work for GAO.